Yuuki's earliest memory is of a stormy winter's night when she was attacked by a vampire, then saved by another. Ten years later, she has grown up a guardian of the vampire race, protecting her savior, Kaname, from discovery as he leads a group of reformed vampires at an elite boarding academy. But at her side is a boy called Zero, who burns with hatred for the creatures who destroyed everything that he ever cared for, and is determined never to trust them. Have the vampires truly renounced their murderous ways, or is there a darker truth behind their actions?

On the surface, Cross Academy is a top of the line, elite boarding school where students come from blue-blood and old money, from all around the world. Divided into two classes, Day and Night, academia and education is around the clock. When students are not in class there is a wide range of clubs and organizations that they can participate in. Need some time away? A bustling town full of shops and cafes lies just beyond the forest that surrounds the Academy. The only thing that Headmaster Kaien asks of his students is that they recognize and follow curfew. "It's a dangerous world these days!"